Head and neck carcinogenesis: impact of MTHFD1 G1958A polymorphism
نویسندگان
چکیده
منابع مشابه
Head and neck carconogenesis: impact of MTHFD1 G1958A polymorphism.
OBJECTIVE To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. METHODS Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) ...
متن کاملHead and neck carcinogenesis: impact of MTHFD1 G1958A polymorphism LIDIA MARIA REBOLHO BATISTA DA SILVA1, JÉSSIKA NUNES GOMES DA SILVA2, ANA LÍVIA SILVA GALBIATTI1, MAYSA SUCCI3, MARIANGELA TORREGLOSA RUIZ4, LUIZ SÉRGIO RAPOSO5, JOSÉ VÍCTOR MANIGLIA6, ÉRIKA CRISTINA PAVARINO-BERTELLI7,
Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) ...
متن کاملAssociation between MTHFD1 G1958A Polymorphism and Neural Tube Defects Susceptibility: A Meta-Analysis
OBJECTIVES The methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, as one of the key genes involved in the folate pathway, has been reported to play a critical role in the pathogenesis of neural tube defects (NTDs). However, the results of published studies are contradictory and inconclusive. Thus, this meta-analysis aimed to evaluate the effect of the common polymorphism in the MTHFD1 gene,...
متن کاملAssociation between HIC1 and RASSF1A Promoter Hypermethylation with MTHFD1 G1958A Polymorphism and Clinicopathological Features of Breast Cancer in Iranian Patients
Background: Ras-associated domain family 1 (RASSF1A) and hypermethylated in cancer (HIC1) genes are methylated more frequently in breast cancer. Genetic factors that alter the DNA methylation levels in normal and tumor tissues could therefore influence the susceptibility to this tumor phenotype. Objective: We determined the frequency of aberrant methylation of HIC1 and RASSF1A gene promoters an...
متن کاملAssociation between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients.
BACKGROUND Ras-associated domain family 1 (RASSF1A) and hypermethylated in cancer (HIC1) genes are methylated more frequently in breast cancer. Genetic factors that alter the DNA methylation levels in normal and tumor tissues could therefore influence the susceptibility to this tumor phenotype. We determined the frequency of aberrant methylation of HIC1 and RASSF1A gene promoters and their ass...
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ژورنال
عنوان ژورنال: Revista da Associação Médica Brasileira (English Edition)
سال: 2011
ISSN: 2255-4823
DOI: 10.1016/s2255-4823(11)70043-1